Alternative splicing as regulator of protein-protein interactions
نویسندگان
چکیده
منابع مشابه
Alternative splicing as regulator of protein-protein interactions
Motivations In recent years, the role of alternative splicing in protein function regulation has been widely investigated. Examples have been reported in which alternative splicing modulates the interaction between two proteins by removing interacting regions. However, despite the large amount of data available about alternative splicing isoforms and protein-protein interactions, only a few sys...
متن کاملRole of alternative splicing in modulating protein-protein interactions
Motivations Alternative splicing (AS) permits the synthesis of multiple transcript variants from a single gene increasing the diversity of proteins encoded by a genome. Through the use of recent highthroughput sequencing technologies, it has been demonstrated that approximately 95% of multi-exon genes undergo AS in panels of human tissues [5], shaping the expressed transcriptome in various ways...
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Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
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Alternative splicing is thought to be one of the major sources for functional diversity in higher eukaryotes. Interestingly, when mapping splicing events onto protein structures, about half of the events affect structured and even highly conserved regions i.e. are non-trivial on the structure level. This has led to the controversial hypothesis that such splice variants result in nonsense-mediat...
متن کاملRole of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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ژورنال
عنوان ژورنال: EMBnet.journal
سال: 2012
ISSN: 2226-6089
DOI: 10.14806/ej.18.a.383